97 Grass Pollen Allergen-induced Surface Expression of CD203C, CD63 and CD107A on CRTH2+ Basophils
نویسندگان
چکیده
منابع مشابه
97 Grass Pollen Allergen-induced Surface Expression of CD203C, CD63 and CD107A on CRTH2+ Basophils: Novel Biomarkers for Monitoring Efficacy of Allergen-specific Immunotherapy
were either unresponsive or showed elevated mRNA levels of the Th1-promoting chemokines CXCL10 and CXCL11. Conclusions: This study supported by grant SFB-F1802 of the Austrian Science Fund shows for the first time that the allergen uptake is specific and similar in DCs from allergic and healthy individuals. More important, the ensuing signal cascade that is triggered by the allergen differs bet...
متن کاملBasophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.
BACKGROUND Immunotherapy inhibits basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immunotherapy withdrawal. OBJECTIVE Intracellular fluorochrome-labeled diamine oxidase (DAO) was used as a novel functional readout of basophil histamine release after immunotherapy. Results were compared with conventional basophil surface expression of activation m...
متن کامل[The usefulness of CD203c expression measurement on basophils after activation with grass pollen and Dermatophagoides pteronyssinus antigens. Preliminary study].
INTRODUCTION 'Gold standard' in the diagnosis of atopic disease are skin prick tests and specific IgE evaluation. Well-established in vitro tests, such as the histamine release test, the leukotriens release test and the flow cytometric basophil activation test can be very helpful in diagnostics, especially when the skin prick test is contraindicated. The aim of this study was to evaluate the us...
متن کاملExploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals
BACKGROUND Sensitization to hazelnut (HN) is frequent and requires clarification to determine whether this sensitization is clinically relevant. The aim of this study was to investigate basophil activation profiles in HN-sensitized and allergic subjects. METHODS Basophil activation was determined by flow cytometric analyses of CD63 and CD203c expression using several HN allergen concentration...
متن کاملOptimizing of the basophil activation test: Comparison of different basophil identification markers.
BACKGROUND Flowcytometric identification of basophils is a prerequisite for measuring activation of basophils with IgE-dependent or IgE-independent stimuli. Aim of this study was to compare different marker combinations in a simultaneous multicolor flowcytometric measurement. METHODS Ten patients with a grass pollen allergy and three controls were included in the study. Basophilic cells were ...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2012
ISSN: 1939-4551
DOI: 10.1097/01.wox.0000411842.94409.90